Category: mjczbpve

5 Questions for Dr. Giselle Sholler, NMTRC

first_imgIntel: What are the challenges of pediatric oncology and how do you tackle those challenges?Sholler: As a pediatric oncologist, one of the most challenging times is when we’re faced with a child who is not responding to standard therapy and we want to figure out how we can treat this patient. How can we bring hope to that family? A project that we are working on in collaboration with TGen, Dell and Intel has brought that hope to these families.Intel: What is the program?Sholler: When a child has an incurable pediatric cancer, we a take a needle biopsy and send it to TGen where the DNA and RNA sequencing occurs. When ready, that information comes back to the Consortium. Through a significant amount of analysis of the genomic information, we’re able to look at what drugs might target specific mutations or pathways. On a virtual tumor board, we have 15 hospitals across the U.S. and now two international hospitals in Lebanon and France that come together and discuss the patient’s case with the bioinformatics team from TGen. Everyone is trying to understand that patient and with the help of pharmacists create individualized treatment plans for that patient so that patient can have a therapy available to them that might result in a response for their tumor.Intel: Why is precision medicine important?Sholler: Precision medicine is about using the genomic information data form a patient’s tumor to identify which drugs not only will work, but which ones may not work on that patient’s specific cancer. With precision medicine, we can identify the right treatment for a patient. We’re not saying chemotherapy is bad, but for many of our patients chemotherapy is attacking every rapidly dividing cell and leaves our children with a lot of long term side effects. My hope for the future is that as we can target patients more specifically with the correct medications, we can alleviate some of the side effects that we’re seeing in our patients. Half our children with neuroblastoma have hearing loss and need hearing aids for the rest of their lives. They have heart conditions, kidney conditions, liver conditions that we’d like to see if we can avoid in the future.Intel: How does the collaboration work to speed the process?Sholler: The collaboration with Dell and Intel has been critical to making this entire project possible. The grant from Dell to fund this entire program over the last four years has been unparalleled in pediatric cancer. The computer power has also been vital to the success. Three years ago we were doing only RNA expression profile and it took two months; now, we’re doing RNA sequencing and DNA exomes completely and it takes less than two weeks to get the answers for our patients. The data transfer and networking used to entail shipping hard drives a few years ago. Now, we can send a tumor sample from Lebanon to TGen, complete the sequence in a few days and have a report for the tumor board a few days after that. It’s just been amazing to see the speed and accuracy improve for profiling.Intel: Anything else?Sholler: Another very critical piece that Dell has helped provide is the physician portal. Physicians are able to work together across the country, and across the world, and have access to patient records. The database now has grown and grown. When we do see patients, we can also pull up previous patients with similar sequencing or similar profiles, or treated with similar drugs, and see what was used in treatment. And how did they do? What was the outcome? We’re learning more and more with every patient and it doesn’t matter where we live anymore. Everything’s virtual online. It’s just been incredible. Giselle Sholler is the Chair of the Neuroblastoma and Medulloblastoma Translational Research Consortium (NMTRC) and the Director of the Hayworth Innovative Therapeutic Clinic at Helen DeVos Children’s Hospital. The NMTRC is a group of 15 pediatric hospitals across the U.S, plus the American University in Beirut, Lebanon, and Hospital La Timone in Marseilles, France. We sat down recently with Dr. Sholler to talk about to role of precision medicine in her work and how it impacts patients.last_img read more

Why is it so hard to squash a cockroach?

first_imgInsects, whether they creep or fly, live in a world of hard knocks. Who has not stepped on a cockroach, then raised her shoe to watch the creature get up and scoot under a door? Bees and wasps, for their part, face a never-ending obstacle course of leaves, stems, and petals—bumblebees crash their wings into obstacles as often as once a second. Now, researchers are learning how these creatures bend but don’t break.The results do more than explain why cockroaches are so hard to kill. By mimicking the combination of rigid and flexible parts that gives insect exoskeletons and wings their resilience, biomechanicists are making robots tougher. “Bend but not break is a lot of what happens in these insects,” says Harvard University roboticist Robert Wood. “We’re trying the same thing to see if we can have similar robustness in our robots.”Until recently, most engineers designed for a tough-and-tumble world by making machines stiff and sturdy or agile enough to avoid danger. Modern cars incorporate a third approach: They absorb impacts by crumpling, sacrificing the structure to protect the occupants. “Nature has come up with a tactic that we don’t have,” says David Hu, a mechanical engineer at Georgia Institute of Technology in Atlanta. “Crumple … and then keep on going.”Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)To see how cockroaches do it, integrative biologist Robert Full at the University of California (UC), Berkeley, and Ph.D. student Kaushik Jayaram coaxed the insects through ever smaller slits or tighter tunnels while filming them with a high-speed video camera. They also lowered weights of up to 100 grams onto different parts of the insects’ bodies and watched how the creatures collapsed.Full and Jayaram found that when the 9-millimeter-tall Periplaneta americana approaches a slit no more than 3 millimeters high, the roach first inspects the opening with its antennae. Then it jams its head through, follows with its front legs, and begins pulling the rest of its body into the breach. The back legs splay but continue to push. In about 1 second, it emerges on the far side unscathed. That ability to squeeze through a tight spot “goes far beyond any other animals that we have measured, except maybe the octopus,” says Stacey Combes, a biologist at UC Davis. But an octopus—a model for the “soft” robots some designers are pursuing—can’t match the speed of a cockroach or other arthropods. “Not only insects, but crabs, spiders, and scorpions are pretty good at going anywhere and are pretty indestructible,” Full says.Jayaram and Full’s study, published this week in the Proceedings of the National Academy of Sciences, showed that the cockroach’s secret lies in a hard but still flexible exoskeleton. It consists of hard yet bendable plates—capable of efficiently transmitting energy to its legs—connected by elastic membranes that allow the plates to overlap as the insect compresses. Thanks to spines that give traction when its legs are splayed, a cockroach can scuttle even at maximum scrunch.At a meeting of the Society for Integrative and Comparative Biology last month in Portland, Oregon, Harvard postdoc Andrew Mountcastle reported that a similar blending of hard and soft parts enables bees and wasps to survive their aerial obstacle courses. Using high-speed video, he found that wasp wings actually buckle during collisions and then snap back into place. He also noticed that the wings have a big patch of an elastic protein called resilin about 65% down the wing. He and Combes hypothesized that the patch serves as a hinge.To test the idea, Mountcastle developed a way to mount a wasp on a rotational motor and hit the wing over and over. “He showed the wing can pop out many, many times,” Hu says. When Mountcastle splinted the hinge so the wing couldn’t buckle, the wing quickly wore down. He and Combes also found that many insects have a similar hinge, but that bumblebee wings incorporate a different design principle. The veins that support the bee wing are concentrated close to the body, resulting in a flexible wingtip that can bounce off obstacles with less wear and tear. “It’s different means to the same ends,” Mountcastle says.Both the roach exoskeleton and the insect wings are inspiring robot design. Jayaram has built a 75-millimeter-tall robot, called CRAM, with a roachlike collapsible exoskeleton and legs with “spines” that work both in the uncompressed and compressed positions. It can squeeze to one-half its height and still move 5 to 10 times faster than soft robots, Jayaram says. “What is exciting is that this gives us an order of magnitude reduction in voids where we can deploy robots,” says Robin Murphy of Texas A&M University, College Station, who specializes in robots for disaster search and rescue operations.Mountcastle has joined forces with Jayaram—now also a Harvard postdoc—and Wood to refit hinged wings to an insect-sized flying robot called Robobee. “Designing [it] was not trivial; they are not simple, linear hinges,” Mountcastle said at the Portland meeting. The group hopes begin testing the new design in the real world by spring.Hu applauds the insect-inspired designs: “It would be great to see more robots built with potential damage in mind.” As for killing cockroaches—Jarayam suggests slamming that shoe hard and holding it down.last_img read more

Alexandre Lacazette chosen as Arsenal’s Player of the Season

first_imgAdvertisement Lacazette wants to give his best for Arsenal regardless of it probably being his last match for themAdvertisementArsenal striker Alexandre Lacazette, who had a season to remember netting 18 goals so far has been crooned the club’s player of the season.Image Courtesy: Sky SportsArsenal forward Alex Lacazette has been awarded with the club’s Player of the Season award after he went on to garner 35% of the fans vote. The Frenchmen has had a memorable season with the Gunners, scoring 18 goals and assisting 12 times in all competitions.Lacazette has also been the integral part of the Arsenal side that currently see them in the semi finals of the Europa League. His 4 goals in the campaign includes a brace vs Valencia in the recently concluded 1st leg that has put the side in the cusp of reaching the finals.Even while the French forward has gone on to score big goals vs Liverpool, Chelsea and Tottenham in his 13 Premier League goals for the season, he has partially been overshadowed by his strike partner Pierre-Emerick Aubameyang who has gone on to register 19 goals this term.Lacazette will be delighted in receiving the award after missing out the majority of the previous season through injury that saw him lose his place in the France world cup squad.Also Read:Chiellini draws comparisons of Federer-Nadal in Ronaldo-Messilast_img read more

Dyche rages at officials after late Man United draw

first_imgSean Dyche was unhappy with a key offside decision and the amount of injury time played in Burnley’s dramatic 2-2 draw with Manchester United at Old Trafford.The Clarets looked to be heading for a first away win over United since 1962 when Chris Wood doubled the lead in the 81st minute after Ashley Barnes had put them ahead.However, a penalty from Paul Pogba gave the Red Devils a lifeline before Victor Lindelof snatched a 92nd-minute equaliser, turning in the rebound after Alexis Sanchez’s header was saved by Tom Heaton. Article continues below Editors’ Picks Man Utd ready to spend big on Sancho and Haaland in January Who is Marcus Thuram? Lilian’s son who is top of the Bundesliga with Borussia Monchengladbach Brazil, beware! Messi and Argentina out for revenge after Copa controversy Best player in MLS? Zlatan wasn’t even the best player in LA! Dyche was frustrated that five minutes of time was added on at the end of the match, while he felt Lindelof had scored from an offside position, but he was nonetheless proud of his players.”It was an excellent performance; we know they are in fine form,” he told BBC Sport. “We were resilient, we are getting harder and harder to beat, and we can score goals as well.”The bravery is coming back to the team. Fantastic credit to the players; [it was] a firm draw. Our performances lately have picked up. Their will, desire and mentality is growing all the time.PIC: Ashley Barnes puts the Clarets ahead at Old Trafford.  pic.twitter.com/FrDyKNfa1N— Burnley FC (@BurnleyOfficial) January 29, 2019″I don’t know where the five minutes of stoppage time came from. That’s a bugbear because it gave the crowd a lift. I also think Lindelof is offside when Alexis Sanchez heads it but, like I say, the margins are tight.”Burnley goalkeeper Heaton, who made seven saves during a fine display against his old club, hopes the result could prove a turning point in their fight against relegation from the Premier League.”It’s a tough one to swallow,” he said. “We were running on empty at the end. Obviously, it’s a little sore right now but going forward it’s an excellent point for us.”They have been on a great run, but we just focused on ourselves, kept our shape right, restricted them, had no fear and I think we approached it well.”They are obviously going to come at you. We defended fantastically for most of it and we will take a lot of positives. A point at Old Trafford in the form they are in is a good one.”We feel like we have turned the corner a little but it’s important we take that momentum forward.”It’s not going to be straight forward between now and the end of the season, but we embrace that challenge, starting with Southampton on Saturday.” Check out Goal’s Premier League 2019-20 fantasy football podcast for game tips, debate and rivalries.last_img read more

Chris Froome confirmed in Team Sky’s squad for Giro d’Italia

first_imgReuse this content Share on LinkedIn … we have a small favour to ask. More people, like you, are reading and supporting the Guardian’s independent, investigative journalism than ever before. And unlike many news organisations, we made the choice to keep our reporting open for all, regardless of where they live or what they can afford to pay.The Guardian will engage with the most critical issues of our time – from the escalating climate catastrophe to widespread inequality to the influence of big tech on our lives. At a time when factual information is a necessity, we believe that each of us, around the world, deserves access to accurate reporting with integrity at its heart.Our editorial independence means we set our own agenda and voice our own opinions. Guardian journalism is free from commercial and political bias and not influenced by billionaire owners or shareholders. This means we can give a voice to those less heard, explore where others turn away, and rigorously challenge those in power.We hope you will consider supporting us today. We need your support to keep delivering quality journalism that’s open and independent. Every reader contribution, however big or small, is so valuable. Support The Guardian from as little as $1 – and it only takes a minute. Thank you. news Support The Guardian Share on Messenger Share on Facebook Share on Pinterest Peter Sagan: ‘Being the pope is much harder than being a cyclist’ Topics Chris Froome Share on Twittercenter_img The Recap: sign up for the best of the Guardian’s sport coverage Cycling Since you’re here… Whether Froome will line-up to target a fifth yellow jersey at the Tour in July will likely be decided by administrators, lawyers and experts considering the salbutamol reading which has left a series of questions unanswered.Amaury Sports Organisation, the Tour organisers, are reportedly prepared to block Froome’s participation if the case is unresolved. “I think it’ll be a huge shame for the race if the defending champion and four-times winner can’t be on that start line, even though the process and the rules say that he can, that’s a huge loss for the sport,” Froome added.A fifth Tour title would see Froome share the record number of victories as Lance Armstrong was stripped of his seven titles.Froome added: “Of course there is an element of risk involved in targeting the Giro before the Tour, but I think I would regret it for the rest of my life if I didn’t give this race a go.“I would love to win the maglia rosa [the Giro race winner’s pink jersey], but I am under no illusions whatsoever about how hard the race will be.”Froome will be joined in the Team Sky squad by Vasil Kiryienka of Belarus, Germany’s Christian Knees and Colombia’s Sergio Henao – all of whom helped him win a fourth Tour last July.Wout Poels of Holland, Spain’s David de la Cruz, Salvatore Puccio of Italy and France’s Kenny Elissonde complete the Team Sky squad. Froome, who lived in Italy in the early part of his career, is racing in the Giro for the first time since 2010, in Team Sky’s debut season.Froome is not the only Briton starting with designs on the pink jersey, as Simon Yates has been named as joint leader of the Australian Mitchelton-Scott squad. Giro d’Italia Read more Read more Share on WhatsApp Chris Froome repeated his hope of being cleared of wrongdoing over an adverse finding for elevated levels of salbutamol after being confirmed as a starter at the Giro d’Italia, which begins in Jerusalem next week.The 32-year-old could be banned for the reading at last year’s Vuelta, which he won. But the Team Sky leader is bidding to prove his use of the substance was legitimate. As the asthma medication is a specified substance, the four-time Tour de France winner can continue racing, much to the chagrin of many of his rivals.“It obviously hasn’t been easy … it hasn’t been easy in the build up to the Giro,” Froome told Eurosport. “I certainly haven’t been charged of anything as of yet and I hope to be fully exonerated of any wrongdoing because I know I didn’t do anything wrong.“I get it, when people look at the sport of cycling, they see what’s happened in the past and people think: ‘Here we go again, it’s history repeating itself.’ This case is not that scenario. I do empathise with people but it’s hugely frustrating that this is now being played out in the public domain.“It’s frustrating, but what can I do? I’ve just got to carry on and try and get this resolved as quickly as possible. It’s a complicated process and we’re trying to follow what’s being laid out to us by the authorities, but it’s not all straight forward and we’re doing the best we can to get it cleared up.”The Giro begins on 4 May, with the first three stages in Israel, and concludes in Rome on 27 May, with Froome bidding to be the winner of all three Grand Tours – of France, Spain and Italy – at the same time. Share via Emaillast_img read more

South Africa face uphill task against West Indies

first_imgSouthampton: After three consecutive defeats, South Africa will eye their first win of the ongoing ICC Cricket World Cup 2019 when they face West Indies at the Hampshire Bowl, here on Monday. After a below par show so far, the Proteas desperately need a win to stay in contention for a spot in the semi-finals. West Indies on the other hand looked slightly better after a win and a loss from their two games. The Jason Holder-led Carribean side kicked-off their campaign on a convincing note with an impressive seven wicket win over Pakistan before suffering a narrow 15 loss to Australia. Also Read – We don’t ask for kind of tracks we get: Bowling coach ArunThe Proteas lost their all three encounters against England, Bangladesh and India. The pacer’s performance in their six wicket loss to India must be heartening for skipper Faf du Plessis and the team management, but it’s the batsmen who need to step-up against a good looking West Indies pace attack. So far, nothing seems to work well for South Africa as pacer Dale Steyn has been ruled out due to injury while Lungi Ngidi is also unfit for the game on Monday. Also Read – Bastian Schweinsteiger announces retirement, could join Germany set-upSouth Africa have plenty to discuss about their inconsistent performance with the bat and their openers – Quinton de Kock and Hashim Amla will have to surely fire against the Windies. However, their middle order looks decent and the lower order has also chipped in with runs. The Proteas now needs to play fearless and attacking cricket. Meanwhile, the Windies will look to rise up from their narrow defeat to Australia, a game which was under their control. While their aggressive opening bowling in the first two matches have impressed everyone and if it happens again, it could be another threat for the Proteans as their openers have failed to fire. It was a poor shot selection by the Carribean batsmen in their run-chase against Australia, which cost them the match. However, having won their opening fixture and pushing closer to victory against Australia, they will be the favourites in Monday’s game. South Africa, however, have a 4-2 advantage over West Indies in World Cup games. Squads: West Indies: Jason Holder (Captain), Fabian Allen, Darren Bravo, Shannon Gabriel, Shimron Hetmyer, Evin Lewis, Nicholas Pooran, Andre Russell, Carlos Brathwaite, Sheldon Cottrell, Chris Gayle, Shai Hope (wicket-keeper), Ashley Nurse, Kemar Roach, Oshane Thomas South Africa: Faf du Plessis (Captain), Aiden Markram, Quinton de Kock (wicket-keeper), Hashim Amla, Rassie van der Dussen, David Miller, Chris Morris, Andile Phehlukwayo, JP Duminy, Dwaine Pretorius, Beuran Hendricks, Kagiso Rabada, Lungi Ngidi, Imran Tahir, Tabraiz Shamsi.last_img read more

Get rid of Modi just as he did high-value notes: CM

first_imgRaniganj/Asansol: Coming down heavily on Narendra Modi, Trinamool Congress supremo Mamata Banerjee urged people to scrap him just as he had scrapped high-value notes during demonetisation.”Remember those days when you were forced to face hardships following the note ban. People got up from the bed early morning and found high-value notes had been banned. Modi said it would bring down terrorist activities but in reality, they have gone up. Just as he had scrapped the high-value notes, you scrap him off in the election by casting your votes against him,” she said while addressing two rallies at Raniganj and Asansol on Friday afternoon. Banerjee said: “Modi has ruined the country economically. People have lost jobs. 12,000 farmers have committed suicide but he is unperturbed, he is going from one state to another to narrate lies during the election meetings.” Banerjee added: “During election meetings in other states, Modi is taking the name of Mamata because he knows that in Bengal, BJP will not be able to do anything. They will get a big zero.”last_img read more

TSX rises amid further signs US housing is on the rebound

TORONTO — The Toronto stock market is higher amid a solid earnings report from the biggest U.S. home improvement retailer and positive U.S. economic data. The S&P/TSX composite index ran up 46.79 points to 15,385.26.The Canadian dollar lost 0.2 of a cent to 91.66 cents US.U.S. markets were higher as economic data showed tame inflation during July and housing starts which surged last month to the highest level in eight months.The Dow Jones industrials was ahead 34.13 points to 16,872.87, while the Nasdaq was up 6.32 points to 4,514.63. The S&P 500 index rose 3.92 points to 1,975.66.Home Depot Inc. reported quarterly profit that increased by 14% to $2.05 billion, or $1.52 per share, beating estimates of $1.44 a share. Its shares jumped more than 4%.

Suspect arrested in Negombo with heroin

A suspect was arrested in Negombo with heroin in his possession, the Police said.The Police said that the suspect had in his possession 2.6 kg of heroin. The heroin was valued at over Rs. 20 million. (Colombo Gazette)

Letter We must do a Means Test to determine a liveable

Dear Editor,Recently there have been discussions between the respective Unions and the Government on increased wages and salaries for public servants and for teachers.What about our pensioners who have given yeoman service to this country and are now paid a pension of $19,000 per month? I am motivated to write on the pension being paid to citizens 65 years and older, with the view that the governmental authorities will do a meaningful review of this pension for the 2018 Budget.Under this administration, in September 2015 it was $17,000 and in 2017 it had increased by $2,000 to $19,000. It can be argued that over the two years there was a 12 percent increase, however is this significant to the pensioners. The Government promised to create an environment which is supportive of socio-economic development with the objective of ensuring a ‘good life’ for all.If we are striving for a ‘good life’ for all, certainly the pension being paid is insufficient and should be addressed as a major priority. This pension, like other pensions globally, should be at a minimum amount for the pensioner to live comfortably, and it is expected that this pension will be subsidized by the pensioner in the form of savings, contributions by relatives, etc in order to meet a liveable amount.Pensions are not increased in an objective manner. Each year it is increased by an incremental percentage, and this is known in the financial literature as Incremental Budgeting. It is the view that Zero-Based Budgeting should be applied to determine a liveable pension. In so doing, it should be revaluated each time a new budget is formulated.The way forward is to do a Means Test, whereby on a monthly basis, an estimated amount is required, for example for food, transportation, utilities, accommodation. If this is done it is obvious that $19,000 is inadequate.When one looks at the upper levels of pensions being paid of over one million dollars per month, why pay the lowest level such a meager amount? We must move away from this incremental approach and do a Means Test to determine a liveable pension, and I can assure you that it will be more than $19,000 a month.It would be failing on my part if I do not mention the pensionable age of 65 years to enjoy a ‘good life’.According to the latest World Health Organisation data, Life Expectancy in Guyana is 64 years for a male and 68 years for a female, a total life expectancy of 66 years and a ranking of 130.It is obvious that the authorities should have an early review on the life expectancy and to lower this pensionable age based on the authentic global statistics.After all, our pensioners also deserve a ‘good life’ and time is running out.Yours sincerely,John M. Seeram Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)RelatedHamilton Green Pension Bill passedMarch 10, 2017In “Politics”Some Pensioners demand increase of $20,000 from next governmentApril 22, 2015In “Politics”GuySuCo pension fund: 2016 audited accounts show $32.8B net deficitJune 6, 2018In “Business” read more

How rugbys Fitzgerald and Hanrahan helped Kerrys Donaghy in injury battle

first_imgKIERAN DONAGHY HAS revealed that he sounded out rugby stars Luke Fitzgerald and JJ Hanrahan for advice as he sought to overcome the injury problems that have made 2014 ‘the hardest year of his career’.Donaghy is part of the Kerry squad that travels to Croke Park for today’s All-Ireland senior football quarter-final against Galway.The Austin Stacks club man is now fully fit after a difficult season where has battled groin and hip injures along with a dislocated shoulder.“It’s been the hardest year of my career,” reveals Donaghy. “For part of 2013, the groin and hip both affected me. I was coming off the pitch after a county league final last December and I was dragging my leg. I knew then I was in bother with it.“It was frustrating then this year doing the rehab work but not getting the results. I talked to Luke Fitzgerald and JJ Hanrahan, they had both had the same injury. They just said it’s a long-standing thing and gave me good advice about working on the mental aspect of it. But it was difficult when you’re an amateur GAA player and also working, so you don’t have the time to put in as much rehab.”After missing most of the league, Donaghy then dislocated his shoulder in a club game in April. He was told that he faced a ten-week spell on the sidelines but Donaghy managed to recover in a seven-week time frame.“If not 100%, then I’m very near it in terms of stamina and mobility. I don’t have eight or nine months of hard training done but if I go on to the pitch, I’m prepared to help this Kerry team in any way I can.”In Donaghy’s absence, Kerry have managed to win the Munster title with young attackers James O’Donoghue and Paul Geaney both stepping up to produce terrific performances in the provincial final last month against Cork.“They’re both playing really good stuff. A lot of marquee forwards have gone from the Kerry squad, so it’s great to see these guys coming in. They’re very talented and doing very well. I suppose it is strange with the amount of older lads that have left the squad but that’s what happens and we’ve had to drive on.” Source: SuperValuIreland/YouTubeSuperValu, proud sponsor of the GAA Football All Ireland Championship, are calling on fans to guess who the Mystery GAA player is using #SVwinningtaste on Twitter or Facebook for a chance to win fantastic prizes, including a VIP Trip to the All-Ireland Football Final.Dublin to face Monaghan while Donegal will play Armagh in All-Ireland quarter-finalsLowry, Mugsy and McDonnell – Twitter’s take on Saturday night football in Croke Parklast_img read more

Et si Inception devenait réalité

first_imgEt si “Inception” devenait réalité ? Des volontaires sont parvenus, grâce à des électrodes implantées directement dans leur cerveau, à faire apparaître et disparaître des images sur un écran par la seule force de la pensée. Suite à ces résultats, le professeur qui a travaillé sur cette expérimentation pense pouvoir construire une machine à interpréter les rêves.L’expérience a été réalisée dans le cadre d’une étude menée par le professeur Moran Cerf, secondé par une équipe de scientifiques du California Institute of Technology de Pasadena, et dont les résultats viennent d’être publiés dans le magazine Nature. Son objectif ? Démontrer comment notre cerveau, sans cesse sollicité par des images, des sons et des odeurs, peut, à travers la pensée, faire un véritable tri de ces informations. Une étude particulièrement intéressante, selon l’expert en neurologie John Donoghe de l’Université Brown, à Rhode Island : “Cela montre qu’il est à présent possible de regarder le processus de réflexion à un niveau jamais atteint auparavant”.Une machine capable d’enregistrer nos rêves ? Douze patients épileptiques, déjà équipés en électrodes, ont participé à cette étude. Les scientifiques leur ont montré sur un écran une série de 110 photos célèbres, comme des portraits de Marilyn Monroe ou des clichés de Michael Jackson. Les chercheurs sont parvenus à identifier des neurones spécifiques répondant chacun à une image unique. Chaque personne dispose à présent de sa base de données “neurone/image”, mise en place par Moran Cerf et son équipe. Grâce aux capteurs implantés dans leur cerveau, les patients mis face à une double image à moitié effacée, ont pu faire apparaître l’une et disparaître l’autre, par la force de la pensée.L’une des applications possibles de cette étude serait alors de pouvoir construire une machine capable d’enregistrer et d’interpréter nos rêves. Un scénario qui rappelle celui de Christopher Nolan, couvert de succès en début d’année : le héros d'”Inception” avait la possibilité d’entrer dans les rêves des autres. Si Moran Cerf parle encore de “science-fiction” pour le moment concernant la machine, il affirme néanmoins que “le cerveau humain est capable de remodeler la réalité, voire même de passer outre notre environnement, grâce au processus de réflexion”.Le 28 octobre 2010 à 12:48 • Emmanuel Perrinlast_img read more

Algues vertes le comité scientifique émet des réserves sur le plan de

first_imgAlgues vertes : le comité scientifique émet des réserves sur le plan de dépollutionLe comité scientifique chargé d’évaluer l’efficacité du plan gouvernemental de lutte contre la prolifération des algues vertes sur les côtes bretonnes a rendu son rapport. C’est un verdict en demi-teinte qui est tombé, l’un des projets pilotes mis en place ayant été jugé “non acceptable en l’état”.Le comité scientifique a émis de “fortes réserves” au sujet de projet concernant la baie de Saint-Brieuc, rapporte le quotidien Ouest-France. Le second plan, visant à lutter contre les algues qui envahissent la baie de Saint-Michel en Grève, a obtenu un avis plus favorable, mais les experts estiment qu’il ne permettra pas lui non plus de “réduire de manière suffisamment drastique” les algues toxiques qui prolifèrent chaque été sur le littoral breton.À lire aussiRéchauffement climatique : les émissions de CO2 connaissent leur plus forte hausse en 7 ansLes scientifiques rappellent que les méthodes proposées ont déjà par le passé révélé leur inefficacité. Ils recommandent alors “une forte réduction de la pression agricole”. Sans quoi “les efforts entrepris aujourd’hui semblent avoir peu de chances d’aboutir aux objectifs escomptés en 2027 par le plan algues vertes, à savoir le bon état écologique des cours d’eau”. Les engrais utilisés par l’agriculture intensive pratiquée en Bretagne sont en effet tenus pour responsables de la propagation des nitrates dans les nappes phréatiques. Un phénomène qui serait à l’origine de la prolifération des algues vertes. Cet avis sera étudié dans les jours à venir par les comités de pilotage du plan de lutte contre cette pollution. Une réflexion qui s’achèvera le 12 avril prochain lors d’une réunion du comité régional de suivi du projet.Le 1 mars 2011 à 18:11 • Emmanuel Perrinlast_img read more

With reservoirs brimming… TS Genco hopes to generate more

first_imgHyderabad: As the main reservoirs of the state are brimming with water, the power generation utility TS Genco is hoping to cross the four-year record of hydel power generation. The officials said that in this financial year they may cross the previous four years generation record of 3,128 MU. The Genco has generated 3,128 MU of power in 2014-15 with plenty of water in the reservoirs in that year. Also Read – JIH organises Eid Milap for sanitary workers Advertise With Us Copious rains this month have given them a lot of hope on using the hydel power generating units to the maximum capacity till for the next few days and to continue generation till summer of next year. Already they have generated about 400 MU in this month. The main multipurpose reservoirs, Srisailam and Nagarjunasagar have received heavy inflow in the past 15 days. The flood was about 8 lakh cusecs per day for nearly a week. Also Read – GHMC distributes saplings to KV students Advertise With Us The flood now has receded, and the Irrigation officials have stopped release of water into the sea and impounding the reservoirs. Director of Hydel Power of Genco Ch Venkata Rajam told The Hans India that the hydel power generation was much hopeful this year. Due to heavy flood, about 35 to 45 MUs of power has been generated at Nagarjunasagar and Srisailam in the past 15 days. Advertise With Us He said that the power generation would be reduced from Thursday onwards. He said that the Irrigation officials have stopped to release the water into the sea. The power generation would be reduced to about 20 MU per day. Venkata Rajam said that from now onwards the power at hydel stations would be generated in the peak hours every day and at the time of contingencies like outage of thermal power units. He said that power would also be generated if the water is released to Krishna Delta. The director said that with the present water levels in the main reservoirs the hydel generation could be continued up to March. He said that if flood water is received in September also, there are chances of augmenting the hydel generation. The Genco has generated about just 285 MUs in 2015-16, 1,300 MUs in 2016-17, and 1,517 MUs in 2017-18. It has generated about 1,751 MU in 2018-19. The officials are expecting to produce two times more power than previous year in 2019-20. The power consumption in the state is about 210 MU per day in the past few days and hydel stations have provided about 40 MUs or about one 20 per cent. The Genco has been providing about 107 MUs per day with the help of its thermal and hydel power generation stations. This has reduced the burden on the power distribution companies in terms of buying the power. Due to lack of enough rains, the power generation at the hydel stations has taken a beating in the past four years. The power utilities have to depend heavily on thermal stations and purchase heavily from the power exchange.last_img read more

Micromax Becomes Worlds Tenth Leading Mobile Phone Company

first_imgDomestic handset manufacturer Micromax has found a place among leading global mobile phone makers, occupying a market share of 1.8 percent in the March quarter, said research firm Gartner.The Gurgaon-based company was ranked as the 10th largest mobile vendor with its total sales hitting 460.3 million units during the January-March quarter, up 2.5 percent in the corresponding quarter a year ago.”In light of their strong smartphone sales in the emerging markets, the Indian and Chinese phone manufacturers increased their footprint during the first quarter of 2015. Six of them were in the top 10 in the first quarter of 2015,” Gartner research director Anshul Gupta told NDTV Profit.However, Korean mobile giant Samsung led the pack with a market share of 21.3 percent, followed by iPhone maker Apple with a share of 13.2 percent.Market shares of Microsoft, LG and Lenovo stood at 7.2 percent, 4.3 percent and 4.2 percent, respectively.Chinese handset maker Xiaomi, which is regarded as the most valuable global startup, has garnered a share of 3.2 percent in the first quarter.Founded in 2010, Xiaomi witnessed rapid growth to emerge as the top smartphone vendor in China, the world’s second largest smartphone market.The company’s smartphone shipments more than tripled to 61.1 million units last year, with revenues seeing a two-fold increase.”During this quarter, local brands and Chinese vendors came out as the key winners in emerging markets. These vendors recorded an average growth of 73 per cent in smartphone sales and saw their combined share go up from 38 per cent to 47 per cent during the first quarter of 2015,” Gupta said.Other top 10 handset vendors include Huawei (4 per cent), TCL Communication (3.1 per cent), and ZTE (2.7 per cent).Globally, smartphone sales recorded an increase of 19.3 percent to 336 million units during the first quarter of this year, largely led by a robust growth in emerging markets other than China.Samsung also maintained its lead on the global smartphone market with a share of 24.2 percent in the first three months of 2015. Apple stood at the second spot with a share of 17.9 percent.last_img read more

CarDekho in aggressive expansion mode to hire 2000 people in tech and

first_imgCarDekhoCarDekho/FacebookAuto tech company CarDekho is planning to increase its headcount by over 2,000 employees by the end of 2019. The company that has a workforce of 2,800 professionals and will be hiring more for their tech and non-tech segments throughout the country.As per the Financial Express report, about 30 percent of the new recruits will be for the tech division and 20 percent for the management verticals related to insurance, fintech, retail and digital.CarDekho has been hiring aggressively for non-tech roles for its channel sales and B2B operations in different cities. The company plans to employ 1,000 people for the above posts from the metro cities and places like Lucknow, Ahmedabad and Pune. However, the auto company is opening new vacancies in the tech vertical to enhance its mobile technologies. It will offer extensive opportunities in open source, front-end and the back-end processing of their online platform.CarDekho has plans to enroll itself in the campus recruitment processes in many colleges by 2020 to grab young talent for its tech and non-tech job profiles.As per the FE report, CarDekho co-founder and CEO Amit Jain said the company is getting successive profits of about 140 percent every year. He aims at opening 150 used car outlets by the end of this fiscal year.last_img read more

Nonprofits Formally Take Over Federal Refugee Program in Texas

first_img Share GABRIEL CRISTÓVER PÉREZ / KUTDemonstrators at Austin-Bergstrom International Airport protest President Trump’s order banning travelers from seven majority-Muslim countries from entering the U.S. last month.Amid some uncertainty and confusion regarding the country’s refugee resettlement program, the federal agency in charge of helping refugees resettle has designated a group of nonprofits that will take over services previously carried out by the State of Texas.The Office of Refugee Resettlement (ORR) selected four “Regional Replacement Designees” to administer the refugee resettlement program in Texas moving forward.Last fall, Texas officially withdrew from the federal Refugee Resettlement Program over a disagreement with the Obama administration regarding refugee screening and the number of people who would be sent to the state.“As a result, Texas will withdraw from the refugee resettlement program,” Gov. Greg Abbott wrote in a statement at the time. “As governor, I will continue to prioritize the safety of all Texans and urge the federal government to overhaul this severely broken system.”In its plan submitted last year, Texas officials had asked ORR officials to promise a tougher screening process for refugees. Because screening is administered by national security agencies, however, ORR couldn’t agree to the terms. So, federal officials said they were unable to approve Texas’ plan.Since the state announced it was leaving the program, local groups and federal workers have been working to come up with a plan to shift the services administered by the state to nonprofits that already work with refugees.Further complicating matters was the new administration’s travel ban, which prohibits some refugees from entering the country. Shortly after taking office, President Trump signed an executive order temporarily banning the resettlement of refugees in the U.S. — and suspended visas for citizens of Syria and six other Middle Eastern and African countries.The ban is currently tied up in court, but in the meantime, many refugees who where slated to come to Texas have been barred from resettling here. Texas resettles roughly 7,000 refugees a year, more than many other states. According to ORR, Midland International Rescue Committee (IRC) is now serving the region including Abilene, Amarillo and El Paso. Catholic Charities Fort Worth is taking over services in the Dallas/Fort Worth area. Refugee Services of Texas is serving the Austin, Corpus Christi and the San Antonio region. Lastly, the YMCA of Greater Houston is taking over resettling refugees in the Houston area.“The Replacement Designees will assume the role previously held by the state of Texas to provide critical services and benefits to refugees and other populations served by ORR in Texas,” ORR officials said in a letter to nonprofits. “ORR values the support and partnership of states, including Texas, to welcome and integrate newcomers into the fabric of our nation.”According to ORR officials this regional structure will be in place “until a later time when proposals and applications will be considered under the Wilson/Fish Program.”A handful of states that have withdrawn from the federal resettlement program eventually transitioned to a Wilson/Program, which is an alternative to typical state and federal partnership programs.last_img read more

Minecrafts indestructible block takes over two hours to destroy

first_imgThough Minecraft is a millennium old at this point (in internet years), the game is still going strong with wacky new projects being completed on a regular basis. This time around, the awesome new project isn’t a world based on a location from your favorite fantasy novel or HBO program, but a rig designed to do the impossible — destroy Minecraft’s indestructible blocks.The indestructible block, Bedrock — otherwise known as Adminium — usually signifies that you’ve gone too far in your mining exploits, and that you need to begin moving horizontally, as there generally isn’t any more room to descend. Because explosions are present in Minecraft — namely through TNT blocks and Creepers — each block has a blast resistance. The stronger the block, the higher the blast resistance. A wood block, which breaks quickly if you punch it with your bare hands, has a blast resistance of 10, while Stone has a resistance of 30. Four block types in the game — Bedrock, a Command Block, an End Portal block, and the End Portal — have the highest resistance in the game, 18,000,000. The second highest blast resistance is just a relatively measly 6000, held by the Anvil, Enchantment Table, and Obsidian block.Explosions in Minecraft also have an associated power level, so in order to blow up Bedrock, the explosion requires a power of 30,000,000. Generating an explosion that powerful is easily achievable when using console commands, but the explosion doesn’t just happen upon the summoning console command. The game has to actually calculate how the explosion will affect every surrounding block that it reaches, and it ends up taking around two-and-a-half hours until the big boom.So, not a practical way to remove some obtrusive Bedrock blocking the construction of your deep, deep underground lair, but fun to know that it’s possible if you feel like waiting around.last_img read more